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So, my roommate is currently watching the episode because she was at work last night. And I just rewatched that first conversation with River and the Doctor and... it doesn't track. It literally makes no sense with what she tells us is supposed to be true later on. Her reaction to the Doctor warning her about danger is to be amused. She doesn't seem to take him seriously at all and it certainly doesn't seem to be causing her pain that he doesn't recognize her (and he obviously doesn't recognize her -- she introduces herself to him). All of that comes later.
However, she does tell us in her opening dialogue with Lux that, "I lied. I always lie." This does make me suspect that she's not on the level about knowing the Doctor in the future. I'm still not sure that I think that she and the other crew members are real -- they could be constructs of the little girl/computer core's mind. She also just doesn't act like she knows him -- his personality, his quirks, what makes him a person.
Anyway, I had to leave the room at that point, because the rest of the crew was being assholish to Evangelista and I know this time around that there's no point to it -- she just gets insulted and then dies horribly. Bleh.