I very much agree on 1 and 8, and I quite like 6 as long as the CSI people don't get their hands on it, as I like River being very important to Simon in a completely and utterly platonic way. Oh, and I agree with 4 too, as why anyone would put up with Jayne as a signifcant other is completely beyond me. I'm generally apathetic on the rest, as I think Simon/Kaylee is cute but haven't considered the long-term potential, and I don't much care who Mal and/or Inara wind up with.

But a very emphatic yes on the Wash/Zoe, and especially on Zoe killing people with her pinky.